Cilostan CR Drug Interactions

Cilostazol is extensively metabolized by CYP enzymes, particularly CYP3A4 and CYP2C19.
Concomitant administration with anticoagulant drugs such as warfarin; platelet aggregation inhibitors like aspirin, ticlopidine etc.; and thrombolytics including urokinase and alteplase may cause bleeding.
Concomitant intake with prostaglandin E1 or derivative (alprostadile, rimaprodex, alphadex, etc) may also cause bleeding.
In patients receiving Cilostazol and inhibitors of CYP3A4 (erythromycin, cimetidine, grape fruit juice) concomitantly, increase in blood levels of these drugs may be observed. In these cases, the administration should be reduced or started at lower dosage.
In patients receiving Cilostazol and organic of CYP3A4 (diltiazem) concomitantly, increase in blood levels of these drugs may be observed. If used concomitantly, the administration should be reduced or started at lower dosage.
In patients receiving Cilostazol and inhibitors of CYP3A4 (omeprazole, etc.) concomitantly, blood levels of these drugs may be increased. If used concomitantly, the administration should be reduced or started at lower dosage.