Celeflam Dosage/Direction for Use

Use lowest effective dose for the shortest duration consistent with treatment goals for the individual patient.
These doses can be given without regard to timing of meals.
Osteoarthritis: For relief of the signs and symptoms of OA, the recommended oral dose is 200 mg per day administered as a single dose or as 100 mg twice daily.
Rheumatoid Arthritis: For relief of the signs and symptoms of RA, the recommended oral dose is 100 to 200 mg twice daily.
Juvenile Rheumatoid Arthritis: For the relief of the signs and symptoms of JRA, the recommended oral dose for pediatric patients (age 2 years and older) is based on weight. For patients ≥10 kg to ≤25 kg, the recommended dose is 50 mg twice daily. For patients >25 kg, the recommended dose is 100 mg twice daily.
For patients who have difficulty swallowing capsules, the contents of a Celecoxib (Celeflam) capsule can be added to applesauce. The entire capsule contents are carefully emptied onto a level teaspoon of cool or room temperature applesauce and ingested immediately with water. The sprinkled capsule contents on applesauce are stable for up to 6 hours under refrigerated conditions (2-8°C/35-45°F).
Ankylosing Spondylitis: For the management of the signs and symptoms of AS, the recommended dose of Celecoxib (Celeflam) is 200 mg daily in single (once per day) or divided (twice per day) doses. If no effect is observed after 6 weeks, a trial of 400 mg daily may be worthwhile. If no effect is observed after 6 weeks on 400 mg daily, a response is not likely and consideration should be given to alternate treatment options.
Management of Acute Pain and Treatment of Primary Dysmenorrhea: The recommended dose of Celecoxib (Celeflam) is 400 mg initially, followed by an additional 200 mg dose if needed on the first day. On subsequent days, the recommended dose is 200 mg twice daily as needed.
Familial Adenomatous Polyposis: Usual medical care for FAP patients should be continued while on Celecoxib (Celeflam). To reduce the number of adenomatous colorectal polyps in patients with FAP, the recommended oral dose is 400 mg twice per day to be taken with food.
Special Populations: Hepatic insufficiency: The daily recommended dose of Celecoxib (Celeflam) capsules in patients with moderate hepatic impairment (Child-Pugh Class B) should be reduced by 50%. The use of Celecoxib (Celeflam) in patients with severe hepatic impairment is not recommended.
Poor Metabolizers of CYP2C9 Substrates: Patients who are known or suspected to be poor CYP2C9 metabolizers based on previous history/experience with other CYP2C9 substrates (such as Warfarin, phenytoin) should be administered Celecoxib (Celeflam) with caution. Consider starting treatment at half the lowest recommended dose in poor metabolizers. Consider using alternative management in JRA patients who are poor metabolizers.