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Acute lethal dose of capecitabine in humans is not known. However, symptoms of overdose may include nausea, vomiting, diarrhea, mucositis, gastrointestinal irritation and bleeding, and bone marrow depression. Severe hand-foot syndrome, mucositis, and diarrhea have been experienced by patients receiving capecitabine 1657 mg/m2 daily (as 2 divided doses) in a continuous daily regimen for at least 6 weeks.
Since there is no known antidote for capecitabine overdose, management consists of discontinuance of the drug and initiation of supportive measures appropriate for the type of toxicity observed. Although no clinical experience using dialysis as a treatment for capecitabine overdose has been reported, dialysis may be of benefit in reducing circulating concentrations of 5'-DFUR, a low molecular-weight metabolite of the parent compound.
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