Cefumax Warnings

Tablets: Clostridium difficile-associated diarrhea (CDAD) has been reported with use nearly all antibacterial agents, including cefuroxime axetil, and may range in severity from mild diarrhea to fatal colitis. Treatment with antibacterial agents alters the normal flora of the colon leading to overgrowth of C. difficile.
Clostridium difficile produces toxins A and B which contribute to the development of CDAD. Hypertoxin producing strains of C. difficile cause increased morbidity and mortality, as these infections can be refractory to antimicrobial therapy and may require colectomy. Clostridium difficile must be considered in all patients who present with diarrhea following antibiotic use. Careful medical history is necessary since CDAD has been reported to occur over 2 months after the administration of antibacterial agents.
If CDAD is suspected or confirmed, ongoing antibiotic use not directed against C. difficile may need to be discontinued. Appropriate fluid and electrolyte management, protein supplementation, antibiotic treatment of C. difficile and surgical evaluation should be instituted as clinically indicated.
Injection: Cefumax should be used with care in patients with hypersensitivity to penicillin.
In the clinical and laboratory tests, cross-allergenicity between penicillin and cephalosporin was ascertained although there were rare cases of patients who have demonstrated allergic reactions to both of these 2 drugs. Some cases of anaphylactic shock were reported especially following the parenteral administration.
During pregnancy and children <3 months, cefumax should be used in cases of absolute necessity and under direct medical control.