Adult: 1,000 mg or 2,000 mg daily as a single dose or in 2 divided doses. Dosage and treatment recommendations may vary between countries (refer to detailed local guidelines). Child: >6 years weighing >40 kg Same as adult dose. Dosage and treatment recommendations may vary between countries (refer to detailed local guidelines).
Oral Complicated urinary tract infections
Adult: 1,000 mg 12 hourly. Dosage, treatment duration, and indication may vary between countries (refer to detailed local guidelines). Child: >6 years weighing >40 kg Same as adult dose. Dosage, treatment duration, and indication may vary between countries (refer to detailed local guidelines).
Oral Skin and skin structure infections
Adult: 1,000 mg once daily. Dosage and treatment recommendations may vary between countries (refer to detailed local guidelines). Child: >6 years weighing >40 kg Same as adult dose. Dosage and treatment recommendations may vary between countries (refer to detailed local guidelines).
Oral Pharyngitis, Tonsillitis
Adult: For cases caused by susceptible strains of Streptococcus pyogenes (group A β-haemolytic streptococci): 1,000 mg daily as a single dose or in 2 divided doses for 10 days. Child: >6 years weighing >40 kg Same as adult dose.
What are the brands available for Cefadroxil in Philippines?
Dosage recommendations may vary between countries (refer to detailed local guidelines).
Administration
Cefadroxil May be taken with or without food. May be taken w/ meals to reduce GI discomfort.
Reconstitution
Powder for oral susp: Reconstitute with the appropriate amount of water as specified on the bottle. Shake well until suspended.
Contraindications
Hypersensitivity to cefadroxil or other cephalosporins; history of severe reactions to penicillins or to any other β-lactam drugs.
Special Precautions
Patient with history of non-severe hypersensitivity to penicillins allergy; history of gastrointestinal disease (e.g. colitis). Renal impairment. Children. Pregnancy and lactation.
Adverse Reactions
Significant: Hypersensitivity reactions including anaphylaxis; fungal or bacterial superinfection (prolonged use). Gastrointestinal disorders: Nausea, vomiting, diarrhoea, dyspepsia, abdominal discomfort, abdominal pain, glossitis. Reproductive system and breast disorders: Vaginal mycoses (genital candidiasis). Skin and subcutaneous tissue disorders: Rash, pruritus, allergic exanthema, urticaria. Potentially Fatal:Clostridioides difficile-associated diarrhoea, pseudomembranous colitis.
Perform culture and sensitivity tests and consult local recommendations before treatment initiation due to antibiotic resistance risks. Monitor renal function. Assess for signs and symptoms of hypersensitivity reactions during 1st dose; severe or bloody diarrhoea.
Overdosage
Symptoms: Nausea, hallucinations, hyperreflexia, extrapyramidal symptoms, clouded consciousness, coma, and renal impairment. Management: Symptomatic treatment. Induce vomiting or perform gastric lavage. May perform haemodialysis if necessary. Monitor and correct water and electrolyte balance. Monitor renal function.
Drug Interactions
May cause antagonistic effect with bacteriostatic agents (e.g. tetracycline, erythromycin, sulfonamides, chloramphenicol). May potentiate nephrotoxic effects with aminoglycoside antibiotic (e.g. polymyxin B, colistin) and high-dose loop diuretics. May increase and sustain serum concentration with probenecid. May attenuate the effect of oral contraceptives. Reduced bioavailability with colestyramine.
Lab Interference
May result in positive direct Coombs test. May cause false-positive reaction for urinary glucose test using Benedict's or Fehling's solutions; false-positive serum or urine creatinine with Jaffe reaction.
Action
Description: Mechanism of Action: Cefadroxil is a 1st generation cephalosporin antibiotic. It binds to 1 or more of the penicillin-binding proteins (PBPs) leading to the inhibition of the final transpeptidase step of peptidoglycan synthesis in the bacterial cell walls, thus inhibiting cell wall synthesis resulting in cell wall assembly arrest and bacterial cell lysis. Pharmacokinetics: Absorption: Almost completely absorbed from the gastrointestinal tract. Time to peak plasma concentration: Within 70-90 minutes. Distribution: Widely distributed to body tissues and fluids. Crosses the placenta and enters breast milk. Volume of distribution: 0.31 L/kg. Plasma protein binding: Approx 20%. Excretion: Via urine (>90% as unchanged drug). Elimination half-life: 1-2 hours.
Chemical Structure
Cefadroxil Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 47965, Cefadroxil. https://pubchem.ncbi.nlm.nih.gov/compound/Cefadroxil. Accessed May 27, 2025.
Storage
Tab/Cap/Powder for oral susp: Store between 15-30°C. Reconstituted powder for oral susp: Store between 2-8°C for 14 days.
J01DB05 - cefadroxil ; Belongs to the class of first-generation cephalosporins. Used in the systemic treatment of infections.
References
Brayfield A, Cadart C (eds). Cefadroxil. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 06/05/2025.Cefadroxil 500 mg Capsules (Gaelic Laboratories Limited). MHRA. https://products.mhra.gov.uk. Accessed 06/05/2025.Cefadroxil Capsule (Lupin Pharmaceuticals, Inc). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 06/05/2025.Cefadroxil Powder, for Suspension (Lupin Pharmaceuticals, Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 19/05/2025.Cefadroxil Tablet (Teva Pharmaceuticals USA, Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 21/05/2025.Cefadroxil. UpToDate Lexidrug, AHFS DI (Adult and Pediatric) Online. American Society of Health-System Pharmacists, Inc. Waltham, MA. UpToDate, Inc. https://online.lexi.com. Accessed 06/05/2025.Cefadroxil. UpToDate Lexidrug, Lexi-Drugs Multinational Online. Waltham, MA. UpToDate, Inc. https://online.lexi.com. Accessed 06/05/2025.Joint Formulary Committee. Cefadroxil. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 06/05/2025.Sofidrox Capsules (Xepa-Soul Pattinson [Malaysia Sdn Bhd]). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my. Accessed 06/05/2025.
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