Mercaptopurine is embryotoxic in rats. This effect is dose dependent.
Normal offspring have been born after Mercaptopurine therapy during human pregnancy, but abortion, prematurity and malformation have been reported.
Mercaptopurine should be used during pregnancy only if the expected benefits to the mother outweigh the potential risks to the fetus.
Mothers receiving Mercaptopurine should not breast feed.
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