Candiva Mechanism of Action

Pharmacology: The active substance of Candiva is Clotrimazole which is biphenyl-(2-Chlorophenyl)-1-imidazolyl-methane.
Clotrimazole (Candiva) has a wide spectrum of activity against Dermatophytes (Trichophyton, Microsporum, Epidermophyton), yeasts (Candida sp., Torulopsis sp.), mould fungi and other fungi (Aspergillus sp., Malassezia furfur, Nocardia sp. etc.).
It also has action against Trichomonas and some strains of Gram-positive bacteria (Streptococci, Staphylococci and Corynebacterium minutissimum) and Gram-negative bacteria (Bacteroides and Hemophilus vaginalis).
Clotrimazole (Candiva) acts on the cell membrane of the fungus.
It appears that it inhibits protein synthesis and influences the utilization and the incorporation of the acylated amino acids essential to fungi.
Radioactive tracer studies have shown excellent penetration of Clotrimazole (Candiva) in various skin layers at highly active concentrations ensuring potent fungicidal activity.