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Film-coated tablet: Citicoline must not be administered with products containing meclofenoxate.
Citicoline potentiates the effects of L-dopa.
Solution for injection: Carbidopa, Levodopa and Entacapone: Citicoline may enhance the effects of levodopa, carbidopa and entacapone. The exact mechanism is unknown, but animal models suggest that citicoline may increase dopamine levels in the brain and/or improve dopaminergic cell survival. In patients with Parkinson's disease, a few studies have demonstrated levodopa-saving effects, whereby the addition of citicoline (500-1,200 mg/day) allowed for lower dosages of levodopa to be used with stable or improved therapeutic efficacy and reduced the side effects in some patients. However, data are limited.
Co-administration with Centrophenoxine: Must not be administered in conjunction with medications containing centrophenoxine.
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