Calcium: Bisphosphonates (e.g., alendronate, etidronate, risedronate) should be taken at least 30 minutes before taking this medicine since calcium may reduce absorption of bisphosphonates.
Quinolones (e.g., ciprofloxacin, norfloxacin, levofloxacin, ofloxacin) should be taken at least three hours before taking this medicine since calcium may reduce absorption of quinolones.
Tetracyclines should be taken at least three hours before taking this medicine to avoid reduced absorption of tetracyclines. Tetracyclines are not recommended in children below 8 years old.
Concomitant intake of calcium and foods rich in oxalic acid (e.g., spinach, sweet potatoes, and beans) or phytic acid (unleavened bread, raw beans, seeds, nuts, and grains) may decrease calcium absorption.
Vitamin D: Concomitant intake of other products containing high dose vitamin D may result in excessive doses of vitamin D.
Concomitant use of mineral oils, olestra, orlistat, and bile acid sequestrants (e.g., cholestyramine, colestipol) may reduce the absorption of vitamin D.
Concomitant use of anticonvulsants, cimetidine and thiazides may decrease the effect of vitamin D.
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