Buscopan Plus Drug Interactions

Hyoscine-N-Butylbromide + Paracetamol (Buscopan Plus) can be taken together with other drugs but not with the following: certain hypnotics and anti-epileptics (e.g. glutethimide, phenobarbital, phenytoin, carbamazepine) as well as rifampicin. The same applies to potentially hepatotoxic substances and alcohol abuse.
Long-term use of paracetamol in patients being treated with oral anti-coagulants is only advisable under medical supervision.
Concomitant use of paracetamol and zidovudine (AZT or retrovir) enhances the tendency towards reducing leukocytes (neutropenia). Therefore, Hyoscine-N-butylbromide + Paracetamol (Buscopan Plus) should only be taken together with zidovudine following medical advice.
The paracetamol dose should be reduced during concurrent administration with probenecid.
Cholestyramine reduces the absorption of paracetamol.
The anticholinergic effect of drugs such as tri- and tetracyclic antidepressants, antihistamines, antipsychotics, quinidine, amantadine, disopyramide and other anticholinergics (e.g. tiotropium, ipratropium, atropine-like compounds) may be intensified by Hyoscine-N-butylbromide + Paracetamol (Buscopan Plus).
Concomitant treatment with dopamine antagonists such as metoclopramide may result in diminution of the effects of both drugs on the gastrointestinal tract.
The tachycardic effects of beta-adrenergic agents may be enhanced by Hyoscine-N-butylbromide + Paracetamol (Buscopan Plus).