Brofoxin Dosage/Direction for Use

Dosage Forms: 1 g Powder for Injection (IM/IV).
Administration Routes: Given as sodium salt by deep intramuscular (IM) injection.
Slow intravenous (IV) injection over 3 to 5 minutes.
Intermittent or continuous IV infusion.
Dosage Equivalents: 1.05 g of cefoxitin sodium ≈ 1 g of cefoxitin.
Usual Adult Dose: 1 or 2 g every 8 hours.
Severe infections: up to 12 g daily.
Pediatric Dosage: Neonates (up to 1 week old): 20-40 mg/kg every 12 hours.
Neonates (1 to 4 weeks old): 20-40 mg/kg every 8 hours.
Older infants and children: 20-40 mg/kg every 6 to 8 hours.
Severe infections: up to 200 mg/kg daily, maximum 12 g daily.
Specific Treatments: Uncomplicated UTI: 1 g IM twice daily.
Uncomplicated gonorrhea: Single dose of 2 g IM with 1 g oral probenecid.
Surgical infection prophylaxis: Adults: 2 g IM or IV 30-60 minutes before procedure, then every 6 hours for up to 24 hours.
Infants/children: 30-40 mg/kg at same intervals as adults.
Neonates: 30-40 mg/kg every 8 to 12 hours.
Cesarean section: Single 2 g IV dose after umbilical cord clamping; optional 3-dose regimen with further 2 g doses 4 and 8 hours later.
Renal Impairment Dosage Adjustments: In adults, after an initial loading dose of 1 to 2 g, maintenance doses are: Creatinine Clearance (CC) 30-50 mL/min: 1-2 g every 8-12 hours.
CC 10-29 mL/min: 1-2 g every 12-24 hours.
CC 5-9 mL/min: 0.5-1 g every 12-24 hours.
CC <5 mL/min: 0.5-1 g every 24-48 hours.
Hemodialysis patients: Repeat loading dose after each session.