Caution in patients w/ thyrotoxicosis; underlying severe heart disease (eg, ischaemic heart disease, arrhythmia or severe heart failure); acute severe asthma. Assess symptoms eg, dyspnoea & chest pain as they may be of either resp or cardiac origin. Additional blood glucose controls are recommended initially in diabetic patients. Risk of serious hypokalemia. Patients w/ persistent asthma who require maintenance therapy w/ β
2-agonists should also receive optimal anti-inflammatory therapy eg, inhaled corticosteroids, leukotriene receptor antagonists, & continued after introduction of Bricanyl even when symptoms decrease. Caution during the 1st trimester of pregnancy, & if used for maintenance, caution at the end of pregnancy because of potential tocolytic effect. Reports of transient hypoglycemia in newborn preterm infants after maternal β
2-agonist treatment.