Bistapro Adverse Reactions

Very common (≥ 1/10), common (≥ 1/100 to <1/10), uncommon (≥ 1/1,000 to <1/100), rare (≥ 1/10,000 to <1/1,000), very rare (<1/10,000).
Psychiatric disorders: Uncommon: Depression, sleep disorders.
Rare: Nightmares, hallucinations.
Nervous system disorders: Common: Dizziness*, headache*.
Rare: Syncope.
Eye disorders: Rare: Reduced tear flow.
Very rare: Conjunctivitis.
Ear and labyrinth disorders: Rare: Hearing disorders.
Cardiac disorders: Very common: Bradycardia (in patients with chronic heart failure).
Common: Worsening of pre-existing heart failure (in patients with chronic heart failure).
Uncommon: AV-conduction disturbances; worsening of pre-existing heart failure (in patients with hypertension or angina pectoris); bradycardia (in patients with hypertension or angina pectoris).
Vascular disorders: Common: Feeling of coldness or numbness in the extremities, hypotension.
Uncommon: Orthostatic hypotension.
Respiratory, thoracic and mediastinal disorders: Uncommon: Bronchospasm in patients with bronchial asthma or a history of obstructive airways disease.
Rare: Allergic rhinitis.
Gastrointestinal disorders: Common: Gastrointestinal complaints such as nausea, vomiting, diarrhoea, constipation.
Hepatobiliary disorders: Rare: Hepatitis.
Skin and subcutaneous tissue disorders: Rare: Hypersensitivity reactions such as itching, flush, rash.
Very rare: Alopecia. Beta-blockers may provoke or worsen psoriasis or induce psoriasis-like rash.
Musculoskeletal and connective tissue disorders: Uncommon: Muscular weakness, muscle cramps.
Reproductive system and breast disorders: Rare: Potency disorders.
General disorders and administration site conditions: Common: Asthenia (in patients with chronic heart failure), fatigue*.
Uncommon: Asthenia (in patients with hypertension or angina pectoris).
Investigations: Rare: Increased triglycerides, increased liver enzymes (ALAT, ASAT).
Applies only to hypertension or angina pectoris: *These symptoms especially occur at the beginning of the therapy. They are generally mild and usually disappear within 1-2 weeks.