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Acute onset of symptomatic hypotension and thrombocytopenia with fatal outcomes occurred in patients administered with more than twice the recommended therapeutic dose.
There is no known specific antidote for bortezomib overdose. Management for bortezomib overdose includes the monitoring of vital signs and provision of appropriate supportive care to maintain blood pressure (e.g., fluids, pressors, and/or inotropic agents) and body temperature.
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