Sign Out
Amlodipine is a dihydropyridine calcium-channel blocker with general properties similar to those of nifedipine but a more prolonged duration of action.
Pharmacokinetics: Amlodipine is well absorbed following oral administration with peak blood concentrations occurring after 6-12 hrs. It has a prolonged terminal elimination t½ of 35-50 hrs and steady-state plasma concentrations are not achieved until after 7-8 days of administration. Amlodipine is extensively metabolized; metabolites are mostly excreted in urine together with <10% of a dose as unchanged drug. Amlodipine is reported to be about 97.5% bound to plasma protein.
Continue with Google