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Patients with renal failure: Amlodipine may be used in such patients at normal doses. Changes in Amlodipine plasma concentrations are not correlated with degree of renal impairment. Amlodipine is not dialyzable.
Patients with Impaired Hepatic Function: As with all calcium antagonists, amlodipine half-life is prolonged in patients with impaired liver function and dosage recommendations have not been established.
Use in Pregnancy & Lactation: Safety of Amlodipine in human pregnancy or lactation has not been established. Amlodipine does not demonstrate toxicity in animal reproductive studies other than to delay parturition and prolong labor in rats at a dose level 50 times the maximum recommended dose in humans. Accordingly, use in pregnancy is only recommended when there is no safer alternative and when the disease itself carries greater risk for the mother and fetus.
Use in Elderly: Normal dosage regimens are recommended. Amlodipine, used at similar doses in elderly or younger patients is equally well tolerated.
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