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Effect of other medicinal products on Lenvatinib: Chemotherapeutic agents: Concomitant administration of Lenvatinib, carboplatin, and paclitaxel has no significant impact on the pharmacokinetics of any of these 3 substances.
Effect of Lenvatinib on other medicinal products: A clinical drug-drug interaction (DDI) study in cancer patients showed that plasma concentrations of midazolam (a sensitive CYP3A and Pgp substrate) were not altered in the presence of Lenvatinib. No significant drug-drug interaction is therefore expected between Lenvatinib and other CYP3A4/Pgp substrates.
Oral contraceptives: It is currently unknown whether Lenvatinib may reduce the effectiveness of hormonal contraceptives, and therefore women using oral hormonal contraceptives should add a barrier method.
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