Bacticef Special Precautions

Superinfection/Clostridium difficile-associated Diarrhea and Colitis: Possible emergence and overgrowth of nonsusceptible bacteria or fungi, especially Enterobacter, Pseudomonas, Enterococci, Staphylococci, or Candida. Careful observation of the patient is essential.
History of GI Disease: Use Cefixime with caution in patients with a history of GI disease, particularly colitis.
Hypersensitivity Reactions: Hypersensitivity reactions such as anaphylaxis (including shock and fatalities), angioedema, serum sickness-like reactions, Stevens-Johnson syndrome, and toxic epidermal necrolysis have been reported. The use of cefixime should be discontinued immediately and appropriate emergency measures should be initiated. Decreased Prothrombin Activity: Prolonged PT and prolonged partial thromboplastin time reported.
Renal Insufficiency: Cefixime should be administered with caution in adult patients with creatinine clearance <20 ml / min.
Use in Pregnancy: Cefixime should not be used in pregnant mothers unless considered essential by the physician.
Use in Lactation: It is unknown whether cefixime is excreted in human breast milk. Cefixime should not be prescribed to breastfeeding mothers.
Pediatric Use: Safety and efficacy not established in children <6 months of age.