Azithromycin, unlike erythromycin and most macrolides, have little or no effect on hepatic cytochrome P450 isoenzymes, hence, may or may not exhibit adverse effects with astemizole, cisapride, and terfenadine.
Giving azithromycin with antacids containing aluminum or magnesium salts can reduce the rate, but not the extent, of its absorption; azithromycin should be given at least 1 hour before or 2 hours after the antacid.
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