Audra Adverse Reactions

The common side effects of fenofibrate therapy are gastrointestinal upsets including anorexia, nausea, and gastric discomfort. Other adverse effects reported to occur less frequently include headache, dizziness, vertigo, fatigue, skin rashes, pruritus, alopecia, impotence, and anemia, leucopenia, and thrombocytopenia. Raised serum-aminotransferase concentrations have occasionally been reported. Elevated creatine phosphokinase concentrations during fenofibrate therapy may be associated with a syndrome of myositis, myopathy, and rarely rhabdomyolysis; patients with hypoalbuminaemia resulting from the nephrotic syndrome or other renal impairment may be at increased risk. Fenofibrate may increase the lithogenic index, but although there have been isolated reports of gallstones there is no evidence that the administration of fenofibrate is associated with an increased frequency of this adverse effects.