Atorvas Description

Each film coated tablet contains Atorvastatin Calcium equivalent to 20 mg or 40 mg Atorvastatin.
Atorvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor (a statin), is a lipid regulating drug with actions on plasma lipids. Inhibition of HMG-CoA reductase leads to reduced cholesterol synthesis in the liver and lower intracellular cholesterol concentrations; this stimulates an increase in low-density-lipoprotein (LDL)-cholesterol receptors on hepatocyte membranes, thereby increasing the clearance of LDL from the circulation. HMG-CoA reductase inhibitors (statins) reduce total cholesterol, LDL-cholesterol, and very-low-density lipoprotein (VLDL)-cholesterol concentrations in plasma. They also tend to reduce triglycerides and to increase high-density lipoprotein (HDL)-cholesterol concentrations.
It is used to reduce LDL-cholesterol, apolipoprotein B, and triglycerides, and to increase HDL-cholesterol in the treatment of hyperlipidemia, including hypercholesterolemia, combined (mixed) hyperlipidemia (type IIa or IIb hyperlipoproteinemia, hypertriglyceridemia (type IV), and primary dysbetalipoproteinemia (type III). Statins can be effective as adjunct therapy in patients with homozygous familial hypercholesterolemia who have some LDL-receptor function. It is also used for cardiovascular risk reduction in patients with atherosclerotic cardiovascular disease or diabetes mellitus.