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Pharmacology: In a study conducted at the UP College of Pharmacy, Lagundi extract has been proven to inhibit the release of leukotrienes (a mediator in the inflamed process) from mast cells.
Lagundi is the only extensively studied cough remedy and antiasthma herbal preparation in the Philippines. The National Integrated Research Program on Medicinal Plants (NIRPOMP) has established in both animal and human studies, the wide margin of safety and efficacy of Lagundi as a cough remedy and antiasthma medicine.
Clinical Studies: Phase III double-blind placebo-controlled trial has shown bronchodilator and antitussive effects.
Numerous randomized double-blind, controlled clinical trials conducted at the PGH, UST and health centers showed that Lagundi syrup is effective in relieving acute cough of moderate severity.
A meta-analysis of clinical trials on Lagundi vs placebo among pediatric patients with acute cough of moderate severity demonstrated that Lagundi syrup resulted in better clinical improvement compared to placebo with a Peto odds ratio of 0.05 significance level.
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