Arostanil Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Caution For Usage Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Exemestane

Indications/Uses

Adjuvant treatment of postmenopausal women w/ oestrogen-receptor +ve invasive early breast cancer following 2-3 yr of initial adjuvant tamoxifen therapy. Advanced breast cancer in women w/ natural or induced postmenopausal status whose disease has progressed following anti-oestrogen therapy.

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Dosage/Direction for Use

Adult & elderly 25 mg tab once daily. Early breast cancer Continue treatment until completion of 5 yr of combined sequential adjuvant hormonal therapy (tamoxifen followed by exemestane), or earlier if tumour relapse occurs. Advanced breast cancer Continue treatment until tumour progression is evident.

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Overdosage

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Administration

Should be taken with food: Take after a meal.

Contraindications

Hypersensitivity. Pre-menopausal women. Pregnancy & lactation.

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Special Precautions

Not to be administered to women w/ premenopausal endocrine status. Assess LH, FSH & oestradiol levels whenever clinically appropriate to ascertain postmenopausal status. +ve doping control test result. Reduction in bone mineral density & increased fracture rate. Assess bone mineral density at commencement of treatment in women w/ osteoporosis or at risk of osteoporosis. May impair ability to drive & use machines. Patients w/ hepatic or renal impairment. Not recommended in childn.

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Use In Pregnancy & Lactation

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Adverse Reactions

Insomnia; headache; hot flushes; nausea; increased sweating; joint & musculoskeletal pain including arthralgia; fatigue. Anorexia; depression; dizziness, carpal tunnel syndrome; abdominal pain, vomiting, constipation, dyspepsia, diarrhea; rash, alopecia; osteoporosis, fracture; pain, peripheral edema.

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Drug Interactions

Reduced AUC & C_max w/ CYP3A4 inducer eg, rifampicin, anticonvulsants (eg, phenytoin & carbamazepine) & herbal prep containing Hypericum perforatum (St. John's wort). Negated pharmacological action w/ oestrogen-containing medicines. Use cautiously w/ CYP3A4 substrates w/ narrow therapeutic window.

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Caution For Usage

For caution against possible variation of physical aspect of medicine... Click to view Arostanil detailed prescribing information

Storage

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Description

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Action

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MIMS Class

Cancer Hormone Therapy

ATC Classification

L02BG06 - exemestane ; Belongs to the class of enzyme inhibitors. Used in treatment of neoplastic diseases.

Regulatory Classification

Presentation/Packing

Form

Arostanil FC tab 25 mg

Packing/Price

28's;30's

Arostanil

exemestane

Manufacturer:

Intas

Distributor:

Sandoz