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Losartan Potassium: Hypotension and tachycardia; bradycardia could occur from parasympathetic (vagal) stimulation. If symptomatic hypotension should occur, supportive treatment should be instituted.
Neither Losartan Potassium nor its active metabolite can be removed by hemodialysis.
Hydrochlorothiazide: Hypokalaemia may be avoided or treated by concurrent use of potassium or a potassium-sparing diuretic and can be reduced by moderate sodium restriction; dilutional hyponatraemia is best treated with water restriction rather than salt therapy; in massive overdosage, treatment should be symptomatic and directed at fluid and electrolyte replacement.
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