Aplosyn Otic Mechanism of Action

Corticosteroid/Anti-Infective.
Fluocinolone acetonide + Polymyxin B sulfate + Neomycin sulfate (Aplosyn Otic) is a potent agent in the treatment of inflammatory and pruritic dermatoses. In relation to other corticosteroids used topically as adjunctive therapy, (Aplosyn Otic) has proved as effective and, in many instances, was effective when other agents gave inadequate therapeutic response.
Neomycin sulfate provides effective local antibacterial action against many gram-positive and gram-negative pathogens, such as Staphylococcus aureus, Streptococci and Proteus vulgaris, encountered in local infections of the ear and adjacent structures.
Polymyxin B sulfate is antibacterial for many gram-negative organisms, including Pseudomonas aeruginosa, a common cause of otitis externa; Escherichia coli and Aerobacter aerogenes. Neomycin sulfate and Polymyxin B sulfate have complementary action against such pathogens as Hemophilus, Corynebacterium, Neisseria, Klebsiella and Pneumococcus. Propylene glycol is a water-miscible vehicle with low surface tension which facilitates spreadability and penetration of the medication. Fluocinolone acetonide, Neomycin sulfate and Polymyxin B sulfate are highly soluble and stable in this vehicle. The relatively slow rate of evaporation maintains the solution state for an adequate time to allow distribution and contact with all parts of the lesion.