Antoreb Special Precautions

Hypersensitivity: Angioedema.
Hypotension and electrolyte/fluid imbalance: In patients who are intravascularly volume-depleted (e.g., those treated with high-dose diuretics), symptomatic hypotension may occur. These conditions should be corrected prior to administration of Losartan Potassium Tablets, or a lower starting dose should be used (see DOSAGE & ADMINISTRATION).
Electrolyte imbalances are common in patient with renal impairment, with or without diabetes, and should be addressed. In a clinical study conducted in type 2 diabetic patients with proteinuria, the incidence of hyperkalaemia was higher in the group treated with Losartan Potassium Tablets as compared to the placebo group; however, few patients discontinued therapy due to hyperkalaemia.
Liver Function Impairment: For patients with a history of hepatic impairment, a lower dose should be considered based on pharmacokinetic findings that show considerably elevated plasma concentrations of losartan in cirrhotic patients (see DOSAGE & ADMINISTRATION and Pharmacology: PHARMACOKINETICS under Actions).
Renal Function Impairment: Changes in renal function, including renal failure, have been recorded in susceptible individuals as a result of inhibiting the renin-angiotensin system; these changes in renal function may be reversible with discontinuation of therapy.
In patients with extraordinary renal artery stenosis or stenosis of the artery in the kidney, other medicines that impact the renin-angiotensin system may raise blood urea and serum evidence. Losartan Potassium formulation has shown similar effects.