Androgel Drug Interactions

Due to changes in the anticoagulant effect (increased effect of oral anticoagulant by modification of the hepatic synthesis of coagulation factors and competitive inhibition of plasma protein binding): more frequent monitoring of prothrombin and international normalised ration (INR) levels are recommended. Patients taking oral anticoagulants require close monitoring, especially at the start or discontinuation of androgen treatment.
The concomitant administration of testosterone and ACTH or corticosteroids may increase the risk of oedemas. Therefore, these medicines should be administered with caution, especially in patients with heart, kidney or liver disease.
Interaction with laboratory tests: Androgens may decrease thyroxin-fixing globulin (TBG) levels, resulting in reduced T4 serum concentrations and increased T3 and T4 resin uptake. However, free thyroid hormone levels remain unchanged and there is no clinical evidence of thyroid insufficiency.
Changes in insulin sensitivity, glucose tolerance, glycaemic control, blood glucose, and glycosylated haemoglobin levels have been reported with androgens. In diabetic patients, a reduction in antidiabetic medicines may need to be considered.
The application of sunscreen or lotion does not reduce the effectiveness of the medicine.
Washing 2 hours after application has no significant effect on blood testosterone concentrations.