Ampimax Tablet Special Precautions

Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported in patients on penicillin therapy including sultamicillin. These reactions are more likely to occur in individuals with a history of penicillin hypersensitivity and/or hypersensitivity to multiple allergens. Careful inquiry should be made concerning previous hypersensitivity to penicillins, cephalosporins or other drugs before initiating therapy with sultamicillin. If an allergic reaction occurs, the drug should be discontinued and appropriate therapy instituted.
Serious anaphylactoid reactions require immediate emergency treatment with epinephrine. Oxygen, IV steroids, and airway management, including intubation, should be administered as indicated.
Clostridium difficile-associated diarrhea (CDAD) and colitis have been reported with the use of nearly all antibacterial agents, including sultamicillin, and may range in severity from mild to life threatening. It is important to consider this diagnosis in patients who present with diarrhea following administration of antibacterial agents.
The renal, hepatic, and hematologic status of patients undergoing prolonged treatment with aminopenicillins should be evaluated periodically, particularly when administered to patients with liver or renal impairment.
Prescribing sultamicillin in the absence of a proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to the patient and increases the risk of antibiotic resistance.
As with other antibacterial agents, long term or repeated use may result in overgrowth of non-susceptible organisms, including fungi.