The most common adverse effects of Amlodipine are associated with the vasodilatory action, such as dizziness, flushing, headache, hypotension and peripheral oedema. Gastro-intestinal disturbances, increased micturition frequency, lethargy, eye pain, and mental depression have also occurred. A paradoxical increase in ischaemic chest pain may occur at the start of treatment and in a few patients excessive fall in blood pressure has led to cerebral or myocardial ischaemia or transient blindness.
There have been reports of rashes, fever, and abnormalities in liver function due to hypersensitivity reactions. Gingival hyperplasia has been reported but is often reversible on drug withdrawal.