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Filgrastim (Recombinant Human Granulocyte Colony Stimulating Factor, rhG-CSF) is a 175 amino acid protein manufactured by recombinant DNA technology by inserting human gene coding for G-CSF into Escherichia coli (E. Coli). The amino acid sequence in Filgrastim is identical to human G-CSF except for the addition of an N-terminal methionine necessary for expression in E. Coli and is not glycosylated.
It is available as single use Pre-Filled Syringe (PFS) of 0.5 mL containing 300 mcg of Filgrastim concentrated solution Ph.Eur. in a sodium acetate aqueous buffer containing sorbitol and polysorbate 80.
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