Adult: Aluminium hydroxide 44 mg and magnesium hydroxide 39 mg per 1 mL oral suspension
As antacid therapy in gastric and duodenal ulcers, gastritis, gastric hyperacidity and heartburn: 10-20 mL tid, given 20-60 minutes after meals and at bedtime, or as required.
Aluminium hydroxide 175 mg and magnesium hydroxide 200 mg per 5 mL oral suspension Aluminium hydroxide 200 mg and magnesium hydroxide 200 mg per 5 mL oral suspension
For the relief of acid indigestion, heartburn and gastrointestinal upset associated with these symptoms: 10-20 mL 4 times daily, given after meals and at bedtime, or as necessary. Max: 80 mL/24 hours. Dosing recommendations and available fixed-dose combinations may vary between countries and individual products (refer to specific product guidelines). Child: Aluminium hydroxide 44 mg and magnesium hydroxide 39 mg per 1 mL oral suspension
Aluminium hydroxide 200 mg and magnesium hydroxide 200 mg per 5 mL oral suspension ≥12 years Same as adult dose.
Aluminium hydroxide 175 mg and magnesium hydroxide 200 mg per 5 mL oral suspension ≥14 years Same as adult dose. Dosing recommendations, available fixed-dose combinations, and approved age groups may vary between countries and individual products (refer to specific product guidelines).
What are the brands available for Aluminium hydroxide + Magnesium hydroxide in Philippines?
Patient with low phosphate diet. Mild to moderate renal impairment. Children and elderly. Pregnancy and lactation.
Adverse Reactions
Significant: Hypophosphataemia (prolonged use); hypermagnesaemia and aluminium accumulation (which may lead to osteomalacia or encephalopathy), particularly with prolonged use in patients with renal impairment. Gastrointestinal disorders: Diarrhoea, constipation, abdominal pain.
Overdosage
Symptoms: Diarrhoea, abdominal pain, vomiting, hypomotility of the bowel; may cause or aggravate intestinal obstruction and ileus in patients at risk. Management: Symptomatic and supportive treatment. Correct fluid deficiency as necessary. Treatment consists of administration of IV Ca gluconate, rehydration, and forced diuresis. Haemodialysis or peritoneal dialysis may be done as necessary in cases of renal impairment.
Drug Interactions
Interferes with the absorption of H2 antagonists, bisphosphonates, fluoroquinolones, glucocorticoids, tetracyclines, vitamins, atenolol, propranolol, metoprolol, chloroquine, hydroxychloroquine, cefdinir, cefpodoxime, dasatinib, diflunisal, digoxin, eltrombopag, elvitegravir, raltegravir, ethambutol, isoniazid, rifampicin, indometacin, Fe salts, ketoconazole, levothyroxine sodium, lincosamides, nilotinib, phenothiazine neuroleptics, penicillamine, rilpivirine, riociguat, rosuvastatin, sodium fluoride, and combination drug containing tenofovir alafenamide, emtricitabine, and bictegravir. May decrease the effect of sodium polystyrene sulfonate. May increase the serum levels of quinidine.
Aluminium hydroxide: May lead to increased aluminium levels with citrates.
Magnesium hydroxide: May increase the excretion of salicylates due to urine alkalinisation.
Action
Description: Mechanism of Action: Aluminium hydroxide and magnesium hydroxide are antacids that neutralise the secreted gastric acid, resulting in increased gastric pH and inhibition of pepsin activity.
Aluminium hydroxide, a slow-acting antacid, reacts with hydrochloric acid in the stomach to form aluminium chloride and water.
Magnesium hydroxide, a fast-acting antacid, reacts with hydrochloric acid in the stomach to form magnesium chloride and water. Duration: Aluminium hydroxide: Up to 3 hours (60 minutes after meals); 20-60 minutes (fasting state). Pharmacokinetics: Absorption: Aluminium hydroxide: Not well absorbed from the gastrointestinal tract.
Magnesium hydroxide: Bioavailability: Approx 15%. Distribution: Magnesium hydroxide: Volume of distribution: 60.2 L. Excretion: Aluminium hydroxide: Via urine (17-30%); faeces (when combined with dietary phosphate in the intestine).
Magnesium hydroxide: Via urine (up to approx 20%); faeces (as unabsorbed drug). Elimination half-life: 8.3 hours.
Chemical Structure
Aluminium hydroxide Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 10176082, Aluminum Hydroxide. https://pubchem.ncbi.nlm.nih.gov/compound/Aluminum-Hydroxide. Accessed Sept. 24, 2024.
Magnesium hydroxide Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 73981, Magnesium Hydroxide. https://pubchem.ncbi.nlm.nih.gov/compound/Magnesium-Hydroxide. Accessed Sept. 24, 2024.
Storage
Store below 30°C. Storage recommendations may vary between individual products (refer to specific product guidelines).
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