Altacef Drug Interactions

Drug/Laboratory Test Interactions: A false-positive reaction for glucose in the urine may occur with copper reduction tests (Benedict's or Fehling's solution), but not with enzyme-based tests for glycosuria. As a false-negative result may occur in the ferricyanide test, it is recommended that either the glucose oxidase or hexokinase method be used to determine blood/plasma glucose levels in patients receiving Cefuroxime (as Axetil). The presence of cefuroxime does not interfere with the assay of serum and urine creatinine by the alkaline picrate method.
Drug/Drug Interactions: Concomitant administration of probenecid with Cefuroxime (as Axetil) tablets increases the area under the serum concentration versus time curve by 50%. The peak serum cefuroxime concentration after a 1.5-g single dose is greater when taken with 1 g of probenecid (mean = 14.8 mcg/mL) than without probenecid (mean = 12.2 mcg/mL).
Drugs that reduce gastric acidity may result in a lower bioavailability of Cefuroxime (as Axetil) compared with that of fasting state and tend to cancel the effect of postprandial absorption.
In common with other antibiotics, Cefuroxime (as Axetil) may affect the gut flora, leading to lower estrogen reabsorption and reduced efficacy of combined oral estrogen/progesterone contraceptives.