Alpurase Special Precautions

Allopurinol should not be used for the treatment of an acute attack of gout; moreover, allopurinol therapy should not be initiated for any purpose during an acute attack. Treatment should not be stopped if any skin reactions or other sign of hypersensitivity develops. A cautious reintroduction at a lower dose may be attempted when mild skin reactions have cleared; allopurinol should not be reintroduced in those patients who have experienced other forms of hypersensitivity reactions. Allopurinol should be administered with care to patients with renal or hepatic impairment, and doses may need to be reduced. In all patients receiving allopurinol, it is advisable to maintain a urinary output of not less than 2 L/day and for the urine to be neutral or slightly alkaline.
Use in lactation: Allopurinol should be used with caution in nursing mothers as it has been reported to be excreted in the breast milk.