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The interaction of Ebastine in combination with either ketoconazole or erythromycin (both known to prolong the QTc interval) has been evaluated. Interaction has been observed with these combinations, resulting in higher Ebastine plasma levels but only in about a 10 msec increase in QTc greater than the increase seen with ketoconazole or erythromycin alone.
When Ebastine is administered with food, there is a 1.5 to 2.0 fold increase in the plasma levels and the AUC of the main active acid metabolite of Ebastine. This increase does not alter the Tmax. The administration of Ebastine with food does not cause a modification in its clinical effect.
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