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Symptoms: Nausea, vomiting, abdominal pain, diaphoresis, generalized weakness and lethargy. If an overdosage of paracetamol is suspected, blood should be withdrawn immediately for paracetamol plasma assay, without regard to the presence or absence of symptomatology.
Treatment: The acute hepatotoxicity and nephrotoxicity of paracetamol can be overcome by the administration of sulfhydryl donors eg, N-acetylcysteine which should be given as soon as possible after ingestion. Treatment after 12 hrs is not effective.
Paracetamol overdosage should be treated with gastric lavage if the patient is seen within 4 hrs of ingestion of Aeknil.
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