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As this drug has the potential to produce local irritation in some patients, concomitant use of other potentially irritating topical products (medicated or abrasive soaps and cosmetics that have a strong drying effect, and products with high concentrations of alcohol, astringents, spices, or lime) should be approached with caution.
As this drug is stable to oxygen and light and chemically non-reactivity, even in combined treatment with other acne drugs such as clindamycin or benzoyl peroxide, interactions do not occur.
As absorption quantity of this drug through skin is little, there is less possibilities to interact with the orally delivered drugs. But avoid the combined treatment with other retinoid or similar mechanism action drugs.
Particular caution should be exercised in using preparations containing sulfur, resorcinol, or salicylic acid in combination with this drug.
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