Adeflo Dosage/Direction for Use

Adults and adolescents 12 years and over: 1 inhalation of Salmeterol Xinafoate 50 mcg + Fluticasone Propionate 250 mcg or 50 mcg/500 mcg a day (morning and evening), approximately 12 hours apart or as prescribed by the physician.
The recommended initial dosage for patients aged 12 years and older based on asthma severity.
Improvement in asthma control following inhaled administration of ADEFLO (salmeterol + fluticasone propionate) can occur 30 minutes of beginning treatment, although maximum benefit may not be achieved for 1 week or longer after starting treatment. Individual patients will experience a variable time to onset and degree of symptom relief.
For patients who do not respond adequately to the starting dosage after 2 weeks of therapy, replacing the current strength of ADEFLO (salmeterol + fluticasone propionate) with a higher strength may provide additional improvement in asthma control.
If a previously effective dosage regimen of ADEFLO (salmeterol + fluticasone propionate) falls to provide adequate improvement in asthma control, the therapeutic regimen should be reevaluated and additional therapeutic options (eg, replacing the current strength of ADEFLO (salmeterol + fluticasone propionate) with a higher strength, adding additional inhaled corticosteroid, initiating oral corticosteroids) should be considered.
Chronic Obstructive Pulmonary Disease: The recommended dosage for patients with COPD is 1 inhalation of ADEFLO (salmeterol + fluticasone propionate) 50 mcg/250 mcg or 50 mcg/500 mcg twice daily (morning and evening, approximately 12 hours apart).
If shortness or breath occurs in the period between doses, an inhaled, short-acting beta-2 agonist should be taken for immediate relief.