Adeflo MDI Overdosage

There are no data available from clinical trials on overdose with Salmeterol and Fluticasone Propionate Pressurized Inhalation CFC Free inhaler; however data on overdose with both drugs are given as follows: The signs and symptoms of Salmeterol overdose are tremor, headache and tachycardia. The preferred antidotes are cardioselective beta-blocking agents, which should be used with caution in patients with a history of bronchospasm. If Salmeterol and Fluticasone Propionate Pressurized Inhalation CFC Free inhaler therapy has to be withdrawn due to overdose of the beta agonist component of the drug, provision of appropriate replacement steroid therapy should be considered. Additionally, hypokalemia can occur and potassium replacement should be considered.
Acute: Acute Inhalation of Fluticasone propionate doses in excess of those recommended may lead to temporary suppression of adrenal function. This does not need emergency action as adrenal function is recovered in a low days, as verified by plasma cortisol measurements.
Chronic overdose of inhaled Fluticasone propionate: Refer to Precautions: risk of adrenal suppression.
Monitoring of adrenal reserve may be necessary. In cases of Fluticasone propionate overdose Salmeterol and Fluticasone Propionate Pressurized Inhalation CFC Free inhaler therapy may still be continued at a suitable dosage for symptom control.