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Pregnancy: There is a limited amount of data from the use of Alteplase (Actilyse) in pregnant women.
Nonclinical studies performed with alteplase in doses higher than human doses exhibited fetal immaturity and/or embryotoxicity, secondary to the known pharmacological activity of the drug. Alteplase is not considered to be teratogenic (see Pharmacology: Toxicology under Actions).
In cases of an acute life-threatening disease the benefit has to be evaluated against the potential risk.
Lactation: It is not known if alteplase is excreted into human milk.
Fertility: Clinical data on fertility are not available for Alteplase (Actilyse). Non-clinical studies performed with alteplase showed no adverse effect on fertility (see Pharmacology: Toxicology under Actions).
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