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Blood glucose-lowering effect of glimepiride may be potentiated by intake of the following drugs. Other oral antidiabetic agents, insulin, ACE inhibitors, coumarin derivatives, quinolones, sulfonamides, tetracyclines, chloramphenicol, MAOI's, cyclophosphamide, fibrates, guanethidine, high dose pentoxifylline, salicylates, phenylbutazone, sulfinpyrazone and probenecid.
Acetazolamide, corticosteroids, estrogens, progesterone, barbiturates, diuretics, epinephrine and other sympathomimetic agents, high doses of nicotinic acid, phenothiazines and phenytoin may weaken blood glucose-lowering action of glimepiride.
Alcohol, beta-blockers, H2 receptor antagonists, clonidine and reserpine may either potentiate or weaken the blood glucose-lowering effect of glimepiride.
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