Croup Drug Summary

Drug	Dosage	Remarks
Epinephrine	Nebulization: Racemic Epinephrine 0.5 mL/kg/dose of 2.25% solution in 3 mL normal saline or sterile water L-Epinephrine 5 mL of 1:1,000 solution or 0.5 mL/kg/dose of a 1 mg/mL preservative-free solution Extremely severe obstruction: 0.01 mg/kg IM as initial dose	Adverse Reactions CNS effects (anxiety, cerebral hemorrhage, dizziness, headache, insomnia); GI effects (dry throat, loss of appetite, nausea/vomiting); Neuromuscular effects (tremor, weakness); Respiratory effects (dyspnea, pulmonary edema); Other effects (ophthalmologic effects, diaphoresis) Special Instruction Administered over 5-15 minutes Patient should be observed for at least 2 hours after treatment with Epinephrine

Drug	Dosage	Remarks
Budesonide	2 mg (as 2 mL solution) by nebulization as a single dose	Adverse Reactions CNS effects (headache, dizziness); GI effects (nausea/vomiting, abdominal pain, weight gain, diarrhea); Respiratory effects (rhinitis, throat irritation, cough, hoarseness, Candida infection in oropharynx); Dermatologic effects (urticaria, rash, dermatitis, skin irritation); Hypersensitivity effects (contact dermatitis, anaphylaxis); Other effect (adrenal suppression) Special Instructions Rinse mouth after treatment to decrease oral candidiasis Contraindicated in primary treatment of status asthmaticus, acute asthma

All dosage recommendations are for children with normal renal and hepatic function unless otherwise stated. 
Not all products are available or approved for above use in all countries. 
Products listed in the Drug Summary are based on indications stated in the locally approved product monographs. 
Please refer to local product monographs in Related MIMS Drugs for country-specific prescribing information.