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Hypersensitivity to the active substance or to any of the excipients (see Description).
Women who are or may potentially be pregnant (see Use in Pregnancy & Lactation).
Severe hepatic impairment [(Child-Pugh Class C) (see Dosage & Administration, Precautions and Pharmacology: Pharmacokinetics under Actions)].
ZYTIGA with prednisone or prednisolone is contraindicated in combination with Ra-223.
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