Zyloric Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Caution For Usage Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Allopurinol

Indications/Uses

Idiopathic gout, uric acid lithiasis, acute uric acid nephropathy; neoplastic & myeloproliferative disease w/ high cell turnover rates in which high urate levels occur either spontaneously or after cytotoxic therapy; certain enzyme disorders ie, hypoxanthine guanine phosphoribosyltransferase eg, Lesch-Nyhan syndrome; glucose-6-phosphatase eg, glycogen storage disease; phosphoribosylpyrophosphate synthetase & amidotransferase; adenine phosphoribosyltransferase. Management of 2, 8-dihydroxyadenine renal stones related to deficient activity of adenine phosphoribosyltransferase & recurrent mixed Ca oxalate renal stones in the presence of hyperuricosuria.

Click to view Zyloric detailed prescribing information

Dosage/Direction for Use

Adult Mild conditions 2-10 mg/kg daily or 100-200 mg daily. Moderately severe conditions 300-600 mg daily. Severe conditions 700-900 mg daily. Childn <15 yr 10-20 mg/kg daily or up to max: 400 mg daily.

Click to view Zyloric detailed prescribing information

Overdosage

View Zyloric overdosage for action to be taken in the event of an overdose.

Administration

Should be taken with food: Take immediately after meals.

Contraindications

Hypersensitivity.

Click to view Zyloric detailed prescribing information

Special Precautions

Discontinue use if hypersensitivity reactions occur. HTN or cardiac insufficiency. Not for asymptomatic hyperuricaemia. Not to be started until acute gout has completely subsided. Conditions w/ increased urate formation eg, malignant disease, Lesch-Nyhan syndrome. Impaction of uric acid renal stones. HLA-B*5801 allele carrier. Increased TSH values on long-term use. Ensure adequate hydration. Not to be taken by patients w/ intolerance, Lapp lactose deficiency or glucose-galactose malabsorption. Concomitant use w/ diuretics. May affect ability to drive & use machines. Renal or hepatic impairment. Pregnancy.

Click to view Zyloric detailed prescribing information

Use In Pregnancy & Lactation

Click to view Zyloric detailed prescribing information

Adverse Reactions

Rash.

Click to view Zyloric detailed prescribing information

Drug Interactions

Increased plasma t_½ of vidarabine. Decreased effect by uricosurics eg, probenecid & large doses of salicylates. Increased risk of prolonged hypoglycaemic activity w/ chlorpropamide. Increased effect of warfarin, other coumarin anticoagulants. Inhibited hepatic oxidation of phenytoin. Inhibited metabolism of theophylline. Increased frequency of skin rash w/ ampicillin or amoxicillin. Enhanced bone marrow suppression by cyclophosphamide. Increased plasma conc of cyclosporin, oxipurinol, serum urate. Doubled plasma C_max & AUC of didanosine. Increased risk of hypersensitivity w/ diuretics, ACE inhibitors. Concurrent use w/ 6-mercaptopurine or azathioprine.

Click to view Zyloric detailed prescribing information

Caution For Usage

For caution against possible variation of physical aspect of medicine... Click to view Zyloric detailed prescribing information

Storage

View Zyloric storage conditions for details to ensure optimal shelf-life.

Description

View Zyloric description for details of the chemical structure and excipients (inactive components).

Action

View Zyloric mechanism of action for pharmacodynamics and pharmacokinetics details.

MIMS Class

Hyperuricemia & Gout Preparations

ATC Classification

M04AA01 - allopurinol ; Belongs to the class of preparations inhibiting uric acid production. Used in the treatment of gout.

Regulatory Classification

Presentation/Packing

Form

Zyloric tab 100 mg

Packing/Price

100's

Form

Zyloric tab 300 mg

Packing/Price

30's

Zyloric

allopurinol

Manufacturer:

Aspen

Distributor:

Zuellig Pharma