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MDV: Xylocaine solution for injection is a sterile, isotonic aqueous solution. The pH of the solution is 5.0 - 7.0.
Polyamp: The active ingredient in XYLOCAINE is lignocaine hydrochloride.
The CAS number for lignocaine hydrochloride (AAN) is 6108-05-0 and lignocaine hydrochloride anhydrous is 73-78-9.
The chemical name for lignocaine hydrochloride is 2-Diethylaminoaceto-2'6'-xylidide. The Australian Approved Name is lignocaine hydrochloride.
Lignocaine is classed as a membrane stabilising agent and is a local anaesthetic of the amide type. It is extremely stable and plain solutions can be sterilised by autoclaving, repeated a maximum of two times if necessary.
Plain aqueous solutions are sterile, isotonic and contain lignocaine hydrochloride, sodium chloride, sodium hydroxide for pH adjustment and water for injections. XYLOCAINE solutions contain no antimicrobial agent and should be used only once and any residue discarded.
Plain aqueous solutions of lignocaine hydrochloride have a pH of 5.0 - 7.0 (approx.). Lignocaine base has a pKa of 7.85 (25°C), an oil/water coefficient of 2.9 and a molecular weight of 234.3.
Excipients/Inactive Ingredients: MDV: 1 ml solution for injection contains: Sodium chloride 6 mg (tonicity contributor), methyl parahydroxybenzoate 1 mg (preservative), sodium hydroxide/hydrochloric acid (to pH 5.0-7.0), water for injections to 1 ml.
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