Vancotex Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Warnings Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Caution For Usage Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Vancomycin HCl

Indications/Uses

Serious or severe β-lactam resistant staph infections in penicillin-allergic patients for infections resistant to other antimicrobial drugs.

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Dosage/Direction for Use

Slow IV infusion Adult 500 mg 6 hrly or 1 g 12 hrly. Childn 44 mg/kg daily in divided dose (6 hrly). Neonate Initially 15 mg/kg followed by 10 mg/kg 12 hrly in the 1st wk of life & 8 hrly up to 1 mth. Renal impairment Initially 15 mg/kg. CrCl 2 mL/min/kg 30.9 mg/kg daily, 1.5 mL/min/kg 23.2 mg/kg daily, 1 mL/min/kg 15.4 mg/kg daily, 0.5 mL/min/kg 7.7 mg/kg daily, 0.2 mL/min/kg 3.1 mg/kg daily. Anephric patient Loading dose: 15 mg/kg w/ subsequent dosage of 1.9 mg/kg daily. Anuria 1 g every 7-10 days. Haemodialysis patient 1 g every 7 days.

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Overdosage

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Contraindications

Hypersensitivity.

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Warnings

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Special Precautions

Discontinue use if bullous disorder is suspected. Avoid rapid bolus administration. Patients w/ inflammatory disorders of the intestinal mucosa; previous hearing loss. Thrombophlebitis; anaesth-induced myocardial depression. Perform serial testing of auditory function; periodic haematological studies, urine analysis, renal & LFTs during treatment. Delay position changes until infusion is completed. Prolonged therapy. Avoid concurrent or sequential use of other nephrotoxic drugs. Renal impairment. Pregnancy & lactation. Elderly.

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Use In Pregnancy & Lactation

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Adverse Reactions

Reversible deafness; hypotension, palpitations, substernal pressure, phlebitis; inj site pruritus, generalised flushing, erythematous macular rash, bullous eruption disorders; overgrowth of nonsusceptible organisms; transient elevations of urea & granular casts in urine; reversible neutropenia, eosinophilia; histamine release w/ chills, nausea, urticaria, fever & rigors, anaphylactoid & hypersensitivity reactions, anaphylaxis; pain, chest & back muscle spasms.

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Drug Interactions

Erythema, histamine ie, flushing & anaphylactoid reactions w/ anaesth. Aggravated ototoxicity w/ diuretics eg, ethacrynic acid, frusemide. In vitro binding by cholestyramine. Careful monitoring w/ concurrent administration of neurotoxic or nephrotoxic drugs eg, amphotericin B, streptomycin, neomycin, gentamicin, kanamycin, amikacin, tobramycin, viomycin, bacitracin, polymyxin B, colistin, cisplatin.

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Caution For Usage

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Storage

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Description

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Action

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MIMS Class

Other Antibiotics

ATC Classification

J01XA01 - vancomycin ; Belongs to the class of glycopeptide antibacterials. Used in the systemic treatment of infections.

Regulatory Classification

Presentation/Packing

Form

Vancotex inj 500 mg

Packing/Price

10 × 1's;1's

Vancotex

vancomycin

Manufacturer:

Fisiopharma

Distributor:

Averroes Pharma