Uroday Drug Interactions

When co-administered with Fosfomycin, metoclopramide significantly lowers the therapeutically effective serum and urine concentrations of Fosfomycin. Other drugs that increase the gastrointestinal motility may produce similar effects.
If Fosfomycin trometamol is taken with food, the plasma, and urinary levels of Fosfomycin decrease. For this reason, it is recommended to take this medicine on an empty stomach or 2 to hours after meal or after taking other medications.
Specific problems concerning INR (International Normalized Ratio) alteration: numerous cases of increased anti-vitamin K antagonist activity have been reported in patients taking antibiotics. Risk factors include serious infections or inflammations, old age and poor general health. Under these circumstances, it is difficult to determine whether the change in the INR is due to infections disease or is caused by the treatment. However, there are certain classes of antibiotics which are more frequently involved, in particular: fluoroquinolones, macrolides, cyclines, co-trimoxazole and certain cephalosporins.
Interaction studies have only been carried out in adults.