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Symptoms and Signs: Profound cardiovascular effects are to be expected, e.g. excessive, posture-sensitive hypotension and sometimes bradycardia. Oliguric renal failure has been reported after massive overdosage of labetalol orally. In one case, the use of dopamine to increase the blood pressure may have aggravated the renal failure.
Treatment: Patients should be laid supine with the legs raised.
Parenteral adrenergic/anticholinergic therapy should be administered as needed to improve circulation.
Haemodialysis removes less than 1% labetalol hydrochloride from the circulation.
Further management should be as clinically indicated or as recommended by the national poison centre, where available.
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