Stripole Dosage/Direction for Use

The intravenous administration of Stripole i.v. is recommended only if oral application is not appropriate. The recommended dose for gastric and duodenal ulcer and moderate and severe reflux esophagitis is one vial of 40 mg Stripole per day. For the long-term management of Zollinger-Ellison-Syndrome and other pathological hypersecretory conditions the recommended daily dose at the beginning of the treatment is 80 mg Stripole. Therefore, the dosage can be titrated up or down as needed using measurements of gastric acid secretion to guide. With doses above 80 mg daily, the dose should be divided and given twice daily. A temporary increase of the dosage above 160 mg pantoprazole is possible but should not be applied longer than required for adequate acid control. In case a rapid acid control is required, a starting dose of 2 x 80 mg Stripole is sufficient to manage a decrease of acid output into the target range (<10 mEq/h) within one hour in the majority of patients. Transition from Stripole to the oral formulation of Stripole should be performed as soon as it is clinically justified. The recommended intravenous dosage is one vial (40 mg pantoprazole) Stripole per day.
Special Patient Populations: Impaired Hepatic Function: A daily dose of 20 mg pantoprazole (half a vial of 40 mg pantoprazole I.V) should not be exceeded in patients with severe liver impairment.
Impaired Renal Function: No dose adjustment is necessary in patients with impaired renal function. Type and duration of treatment: As soon as oral therapy is possible, treatment with Stripole should be discontinued and 40 mg pantoprazole p.o. should be administered instead.
Route of Administration: Intravenous (IV).