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Pharmacology: Pharmacodynamics: Preclinically, ambroxol has been shown to increase respiratory tract secretion. It enhances pulmonary surfactant production and stimulates ciliary activity. These actions result in improved mucus flow and transport (mucociliary clearance has been shown in clinical pharmacologic studies. Enhancement of fluid secretion and mucociliary clearance facilitates expectoration and eases cough.
Pharmacokinetics: Ambroxol hydrochloride is a metabolite of bromhexine which is a mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. It alters the structure of mucus to decrease its viscosity and therefore, facilitate its removal by ciliary action or expectoration.
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