Solu-Medrol Dosage/Direction for Use

Methylprednisolone sodium succinate may be administered by intravenous (IV) injection or infusion, or by intramuscular (IM) injection. The preferred method for initial emergency use is IV injection. Dosage may be reduced for infants and children but should be selected based on the severity of the condition and the response of the patient rather than on the age or weight of the patient. The pediatric dosage should not be less than 0.5 mg/kg every 24 hours.
Dosage requirements are variable and must be individualized on the basis of the disease under treatment, its severity and the response of the patient over the entire duration of treatment. A risk/benefit decision must be made in each individual case on an ongoing basis.
The lowest possible dose of corticosteroid should be used to control the condition under treatment for the minimum period. The proper maintenance dosage should be determined by decreasing the initial drug dosage in small decrements at appropriate time intervals until the lowest dosage, which will maintain an adequate clinical response, is reached.
If after long-term therapy the drug is to be stopped, it needs to be withdrawn gradually rather than abruptly (see Precautions).
Following the initial emergency period, consideration should be given to employing a longer acting injectable preparation or an oral preparation. (See Table 1.)

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To avoid compatibility and stability problems, it is recommended that methylprednisolone sodium succinate be administered separately from other drugs whenever possible, as either IV push, through an IV medication chamber, or as an IV "piggy-back" solution, or via an infusion pump (see Special Instructions for Use/Handling under Cautions for Usage).
NOTE: Some of the methylprednisolone sodium succinate formulations come with a diluent that contains benzyl alcohol (see Use in Children under Precautions). The amount of benzyl alcohol per mL is 9 mg.